The arts of rule cover the exercise of power by princes and popular sovereigns, but they range beyond the domain of government itself, extending to civil associations, political parties, and religious institutions. Making full use of political philosophy from a range of backgrounds, this festschrift for Harvey Mansfield recognizes that although the arts of rule are comprehensive, the best government is a limited one.

Lindquist et al. convincingly argue that the brain implements psychological operations that are constitutive of emotion rather than modules subserving discrete emotions. However, thenatureof such psychological operations is open to debate. I argue that considering appraisal theories may provide alternative interpretations of the neuroimaging data with respect to the psychological operations involved.

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error (...) computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)

The behavior of people in the presence of scarce resources has long been a source of ethical concern and debate. Many of the responses, ranging from outright brutality and cheating on the one hand to altruism, nobility, and sacrifice on the other, were most recently demonstrated in the movie Titanic. It should come as no surprise, then, that rational efforts to allocate the very scarce life-saving resource of organs are sometimes circumvented by these natural human impulses and sheer human creativity. (...) This is especially true when the organs in question are required for continued life and cannot be temporarily or permanently replaced by technology. Thus the focus of this paper will be on the competition for livers. (shrink)

The article offers an approach to inquiry about, the foundation of medical ethics by addressing three areas of conceptual presupposition basic to medical ethical theory. First, medical ethics must presuppose a view about the nature of medicine. it is argued that the view required by a cogent medical morality entails that medicine be seen both as a healing relationship and as a practical art. Three ways in which medicine inherently involves values and valuation are presented as important, i.e., in being (...) aimed at the good of health, in being a cognitive art evaluating towards that good, and as a manifestation of a virtuous disposition concerning that good. Finally, a value ontology drawn from these considerations is seen as necessarily underlying medical ethics. A set of three such basic values are promoted as crucial: the value of health; the value of the individual patient; and the value of altruism that mediates the class of potential patients. (shrink)

Research on value congruence rests on the assumption that values denote desirable behaviors and ideals that employees and organizations strive to approach. In the present study, we develop and test the argument that a more complete understanding of value congruence can be achieved by considering a second type of congruence based on employees’ and organizations’ counter-ideal values. We examined this proposition in a time-lagged study of 672 employees from various occupational and organizational backgrounds. We used difference scores as well as (...) polynomial regression and response surface analyses to test our hypotheses. Consistent with our hypotheses, results reveal that counter-ideal value congruence has unique relations to employees’ trust in the organization that go beyond the effects of ideal value congruence. We discuss theoretical and practical implications of this expanded perspective on value congruence. (shrink)

This article asks under what circumstances controversial technologies would be considered seriously for remediation instead of being rejected out of hand. To address this question, the authors developed a conceptual framework called public acceptability of controversial technologies. PACT considers site-specific, decision-oriented dialogues among the individuals and groups involved in selecting or recommending hazardous waste remediation technologies. It distinguishes technology acceptability, that is, a willingness to consider seriously, from technology acceptance, the decision to deploy. The framework integrates four dimensions: an acceptability (...) continuum that underlies decision-oriented dialogues among individuals and constituency groups, the attributes of these individuals and groups, the attributes of the technology at issue, and the community context—social, institutional, and physical. This article describes and explores PACT as a tool for understanding and better predicting the acceptability of controversial technologies. (shrink)

Background Since the enactment of the euthanasia law in the Netherlands, there has been a lively public debate on assisted dying that may influence the way patients talk about euthanasia and physician-assisted suicide with their physicians and the way physicians experience the practice of EAS. Aim To show what developments physicians see in practice and how they perceive the influence of the public debate on the practice of EAS. Methods We conducted a secondary analysis of in-depth interviews with 28 Dutch (...) physicians who had experience with a complex case of EAS. Respondents were recruited both by the network of physicians working for SCEN as well as via a national questionnaire, wherein participating physicians could indicate their willingness to be interviewed. Results Three themes came up in analysing the interviews. First, the interviewed physicians experienced a change in what patients would expect from them: from a role as an involved caregiver to being the mere performer of EAS. Second, interviewees said that requests for EAS based on non-medical reasons came up more frequently and wondered if EAS was the right solution for these requests. Last, respondents had the impression that the standards of EAS are shifting and that the boundaries of the EAS regulation were stretched. Conclusions The perceived developments could make physicians less willing to consider a request for EAS. Our results also raise questions about the role of physicians and of EAS in society. (shrink)

Cognitive neuroscience aims to map mental processes onto brain function, which begs the question of what “mental processes” exist and how they relate to the tasks that are used to manipulate and measure them. This topic has been addressed informally in prior work, but we propose that cumulative progress in cognitive neuroscience requires a more systematic approach to representing the mental entities that are being mapped to brain function and the tasks used to manipulate and measure mental processes. We describe (...) a new open collaborative project that aims to provide a knowledge base for cognitive neuroscience, called the Cognitive Atlas, and outline how this project has the potential to drive novel discoveries about both mind and brain. (shrink)

BackgroundIn research ethics, the most basic question would always be, “which is an ethical issue, which is not?” Interestingly, depending on which ethics guideline we consult, we may have various answers to this question. Though we already have several international ethics guidelines for biomedical research involving human participants, ironically, we do not have a harmonized document which tells us what these various guidelines say and shows us the areas of consensus. In this manuscript, we attempted to do just that.MethodsWe extracted (...) the imperatives from five internationally-known ethics guidelines and took note where the imperatives came from. In doing so, we gathered data on how many guidelines support a specific imperative.ResultsWe found that there is no consensus on the majority of the imperatives and that in only 8.2 % of the imperatives were there at least moderate consensus. Of the 12 clusters, Informed Consent has the highest level of consensus and Research Collaboration and Regulatory Sanctions have the least.ConclusionThere was a lack of consensus in the majority of imperatives from the five internationally-known ethics guidelines. This may be partly explained by the differences among the guidelines in terms of their levels of specification as well as conceptual/ideological differences. (shrink)

lecting statistics about missing bindings and macros, and other errors. This guides debugging and development efforts, leading to iterative improvements in both the tools and the quality of the converted corpus. The build system thus serves as both a production conversion engine and software test harness. We have now processed the complete arχiv collection through 2006 consisting of more than 400,000 documents (a complete run is a processor-yearsize undertaking), continuously improving our success rate. We are now able to convert more (...) than 90% of these documents to XHTML+MathML. We consider over 60% to be successes, converted with no or minor warnings. While the remaining 30% can also be converted, their quality is doubtful, due to unsupported macros or conversion errors. (shrink)

Background In the EU, clinical assessors, rapporteurs and the Committee for Medicinal Products for Human Use are obliged to assess the ethical aspects of a clinical development program and include major ethical flaws in the marketing authorization deliberation processes. To this date, we know very little about the manner that these regulators put this obligation into action. In this paper, we intend to look into the manner and the extent that ethical issues discovered during inspection have reached the deliberation processes. (...) Methods To gather data, we used the Dutch Medicines Evaluation Board database and first searched for the inspections, and their accompanying site inspection reports and integrated inspection reports, related to central marketing authorization applications of drugs submitted to the European Medicines Agency from 2011 to 2015. We then extracted inspection findings that were purely of ethical nature, i.e., those that did not affect the benefit/risk balance of the study. Only findings graded at least major by the inspectorate were included. Lastly, to identify how many of the ethically relevant findings reach the application deliberation processes, we extracted the relevant joint response assessment reports and reviewed the sections that discussed inspection findings. Results From 2011 to 2015, there were 390 processed applications, of which 65 had inspection reports and integrated inspection reports accessible via the database of the Dutch Medicines Evaluation Board. Of the 65, we found ERFs in 37. The majority of the ERFs were graded as major and half of the time it was informed-consent related. A third of these findings were related to research ethics committee processes and requirements. Of the 37 inspections with ERFs, 30 were endorsed in the integrated inspection reports as generally GCP compliant. Day 150 joint response assessment reports and Day 180 list of outstanding issues were reviewed for all 37 inspections, and none of the ERFs were carried over in any of the assessment reports or list of outstanding issues. Conclusion None of the ethically relevant findings, all of which were graded as major or critical in integrated inspection reports, were explicitly carried over to the joint assessment reports. This calls for more transparency in EMA application deliberations on how ERFs are considered, if at all, in the decision-making processes. (shrink)

Christian health care professionals in our secular and pluralistic society often face uncertainty about the place religious faith holds in today's medical practice. Through an examination of a virtue-based ethics, this book proposes a theological view of medical ethics that helps the Christian physician reconcile faith, reason, and professional duty. Edmund D. Pellegrino and David C. Thomasma trace the history of virtue in moral thought, and they examine current debate about a virtue ethic's place in contemporary bioethics. Their proposal (...) balances theological ethics, based on the virtues of faith, hope, and charity, with contemporary medical ethics, based on the principles of beneficence, justice, and autonomy. The result is a theory of clinical ethics that centers on the virtue of charity and is manifest in practical moral decisions. Using Christian bioethical principles, the authors address today's divisive issues in medicine. For health care providers and all those involved in the fields of ethics and religion, this volume shows how faith and reason can combine to create the best possible healing relationship between health care professional and patient. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Virtue as "Likeness to God" in Plato and SenecaDaniel C. Russell (bio)In The Center Of Raphael's Famous Painting"The School of Athens," Plato stands pointing to the heavens, and Aristotle stands pointing to the ground; there stand, that is, the mystical Plato and the down-to-earth Aristotle. Although it oversimplifies, this depiction makes sense for the same reason that Aristotle continues to enjoy a presence in modern moral philosophy that (...) Plato does not: quite simply, Plato's ethics looks too fantastic. And Plato's ethics never looks more fantastic than in the claim that our highest good is to be like God.We find this view, in various forms, in the Phaedrus, Timaeus, Laws, Republic, and Theaetetus, as well as in the Phaedo and Philebus,1 and the ancient Platonist Alcinous in his Handbook of Platonism tells us that likeness to God () is Plato's "official" position on our final end.2 Nonetheless, this view receives very little press today: many philosophers are unaware of it; some have simply ignored it or dismissed it as an idle metaphor; and most of those who have taken it more seriously have also tended to find it too otherworldly to be of much relevance to us. This latter response is due in large measure to viewing likeness to God from the perspective of the ancient Neoplatonist Plotinus.3 But there is certainly no guarantee that Plotinus's perspective on likeness to God gives us an especially accurate reconstruction of Plato's view; indeed, the interpretation of this idea was a matter of considerable controversy among Neoplatonists, some of whom offered far less other-worldly interpretations than Plotinus's.4 [End Page 241]In any event, unraveling likeness to God in Plato requires a fresh approach that makes the greatest sense of it within Plato's larger moral philosophy. And in fact we find just such a promising understanding of likeness to God when we take a fresh look at it through Stoic lenses, and through the lens of Plato's Philebus: in both we find the idea that virtue is part of the divine realm right alongside the down-to-earth idea that virtue is rational activity in relation to the world as we find it. This is not to suppose that the Stoic conception of likeness to God is an interpretation of, or descended from, Plato's conception.5 It is simply that the Stoics also found it helpful to think of virtue as likeness to God, and it will be enough if the Stoic conception opens up the range of possibilities for understanding such an idea, allowing us to see philosophical alternatives that might take us some distance towards interpreting Plato, and that may have remained otherwise out of view. Such an understanding of the idea that virtue is likeness to God as we find in the Stoics, I argue, offers just this sort of promising and unexplored alternative in Platonism.One thing that is quite clear is that Plato means for likeness to God to offer us some insight into the nature of virtue. We see this in the Timaeus, where Plato offers a model of the three-part soul, in which mastery of the parts is justice (42 a-b) and happiness (90b-d), and is what likeness to God comes to (42b-d, 47a-c); clearly, then, the virtue in question is moral virtue. Rather curiously, Plato depicts this constitution of soul as a sort of motion which is of the same kind as the motion of the universe itself (90c-d):6 as the universe consists in orbits which are orderly and reconciled in their motion, so the human soul consists in the different orbits (44d) of reason, passion, and desire, which are out of harmony when we start life, but become more orderly as we mature (43a-44d). Although this is difficult talk, it is clearly meant to depict a self-mastery of the whole soul under [End Page 242] the leadership of reason (43a-44d), which is the same as justice, and which consists in the reconciliation of one's inner motions by reason (42b-d).7 Thus we "stabilize the... (shrink)

In his 1918 logical atomism lectures, Russell argued that there are no molecular facts. But he posed a problem for anyone wanting to avoid molecular facts: we need truth-makers for generalizations of molecular formulas, but such truth-makers seem to be both unavoidable and to have an abominably molecular character. Call this the problem of generalized molecular formulas. I clarify the problem here by distinguishing two kinds of generalized molecular formula: incompletely generalized molecular formulas and completely generalized molecular formulas. I (...) next argue that, if empty worlds are logically possible, then the model-theoretic and truth-functional considerations that are usually given address the problem posed by the first kind of formula, but not the problem posed by the second kind. I then show that Russell’s commitments in 1918 provide an answer to the problem of completely generalized molecular formulas: some truth-makers will be non-atomic facts that have no constituents. This shows that the neo-logical atomist goal of defending the principle of atomicity—the principle that only atomic facts are truth-makers—is not realizable. (shrink)

Exploring the moral foundations of the healing relationship, Edmund D. Pellegrino and David C. Thomasma offer the health care professional a highly readable Christian philosophy of medicine. This book examines the influence religious beliefs have on the kind of person the health professional should be, on the health care policies a society should adopt, and on what constitutes healing in its fullest sense. Helping and Healing looks at the ways a religious perspective shapes the healing relationship and the ethics (...) of that relationship. Pellegrino and Thomasma seek to clarify the role of religious belief in health care by providing a moral basis for such commitment as well as a balancing role for reason. This book establishes a common ground for believers and skeptics alike in their dedication to relieve suffering by showing that helping and healing require an involvement in the religious values of patients. It clearly argues that religion provides crucial insights into medical practice and morality that cannot be ignored, even in our morally heterogeneous society. Central to the authors' message is the concept of patients' vulnerabilities and the need to help them recover not only from the disease but also from an existential assault on their personhood. They then show how this understanding can move caregivers to view their professions as vocations and thereby change the nature of health care from a business to a community of healing. Physicians, nurses, administrators, clergy, theologians, and other health professionals and church leaders will find this volume helpful for their own reflections on the role of religion in the health care ministry and for making a religious commitment integral to their professional lives. (shrink)

Contrary to John Bramhall and critics like him, Thomas Hobbes takes the view that no account of liberty or freedom can serve as the relevant basis on which to distinguish moral from nonmoral agents or explains the basis on which an agent becomes subject to law and liable to punishment. The correct compatibilist strategy rests, on Hobbes’s account, with a proper appreciation and description of the contractualist features that shape and structure the moral community. From this perspective human agents may (...) indeed use their liberty to make themselves moral agents. In doing this, however, they are not employing a distinct kind of liberty but rather using a liberty that they share with animals and other nonmoral agents to perform a distinct kind of act (i.e., consent) whereby they become moral agents subject to law and any punishments that are required to enforce it. ____ -/- Originally published in the Oxford Handbook of Philosophy in Early Modern Europe - eds. D. Clarke & C. Wilson, OUP 2011 -/- Republished in Recasting Hume and Early Modern Philosophy: Selected Essays - OUP 2021: Paul Russell]. (shrink)

The argument and discussion in this paper begins from the premise that Hume was an atheist who denied the religious or theist hypothesis. However, even if it is agreed that that Hume was an atheist this does not tell us where he stood on the question concerning the value of religion. Some atheists, such as Spinoza, have argued that society needs to maintain and preserve a form of “true religion”, which is required for the support of our ethical life. Others, (...) such as D’Holbach have argued that religion is not only false it is pernicious and it should be eradicated. This paper argues that Hume rejected both these proposals, on the ground that they rest, in different ways, on excessively optimistic assumptions. The sensible, practical form of atheism that Hume defends has a more modest and realistic aim, which is simply to restrict and limit the most pernicious forms of religion. Understood this way, Hume’s practical atheism is very different from the forms of “old” atheism associated with Spinoza and D’Holbach, as well as from the “new atheism” of thinkers such as Dawkins and Dennett. -/- Reprinted in Paul Russell, "Recasting Hume and Early Modern Philosophy: Selected Essays" (New York: Oxford University Press, 2021): 340-383. (shrink)

Pellegrino's philosophy of medicine is explored in categories such as the motivation in constructing a philosophy of medicine, the method, the starting point of the doctor-patient relationship, negotiation about values in this relationship, the goal of the relationship, the moral basis of medicine, and additional concerns in the relationship (concerns such as gatekeeping, philosophical anthropology, axiology, philosophy of the body, and the general disjunction between science and morals). A critique of this philosophy is presented in the following areas: methodology, relation (...) to ontology and sociology, the dynamic of individual and social concerns, and the new social condition of medicine. Finally, some suggestions for the future revitalization of philosophy of medicine are made based on Pellegrino's ideas. The focus throughout is on the moral basis and moral consequences of the philosophy of medicine, and not on other important themes. Keywords: doctor-patient relationship, goal of medicine, medical ethics, philosophical method, philosophy of medicine, philosophy of the body, values in medicine CiteULike Connotea Del.icio.us What's this? (shrink)

For Bernard Williams, philosophy and history are importantly connected. His work exploits this connection in a number of directions: he believes that philosophy cannot ignore its own history the way science can; that even when engaging with philosophy’s history primarily to produce history, one needs to draw on philosophy; and that when doing the history of philosophy primarily to produce philosophy, one still needs a sense of how historically distant past philosophers are, because the point of reading them is to (...) confront something different from the present. But Williams also holds that systematic philosophy itself needs to be done historically, engaging not just with its own history, but with that of the concepts it seeks to understand. To explore these different ways in which philosophy and history intertwine, this volume assembles specially commissioned contributions by A. W. Moore, Terence Irwin, Sophie-Grace Chappell, Catherine Rowett, Marcel van Ackeren, John Cottingham, Gerald Lang, Lorenzo Greco, Paul Russell, Carla Bagnoli, Peter Kail, David Owen, Giuseppina D’Oro, James Connelly, Matthieu Queloz, Nikhil Krishnan, John Marenbon, Ralph Wedgwood, Garrett Cullity, Hans-Johann Glock, Geraldine Ng, Ilaria Cozzaglio, Amanda R. Greene, and Miranda Fricker. They critically appraise Williams’s work in and on the history of philosophy as well as his historicist turn and his use of genealogy. The resulting collection uniquely combines substantive discussions of historical figures from Homer to Wittgenstein with methodological discussions of how and why the history of philosophy should be done, and how and why philosophy should draw on history. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Causes of WarBertrand RussellRussell’s authorship of this anonymously published entry in An Encylopaedia of Pacifism (London: Chatto & Windus, 1937), pp. 12–13, has only just come to light, thanks to the recent sale at auction of a letter to him from Aldous Huxley. If this determination had been made earlier, the text would have featured in Papers 21. In acknowledging receipt of “Causes of War” on 14 December 1936, (...) Huxley, the volume’s editor, also wondered whether Russell would like to examine his subject “at greater length—say in 1,000 words” (internet print, ra3 1,850). The original editorial plan, to which Russell must have adhered, allocated a single page to each topic, which ranged alphabetically from “Armaments, Private Manufacture of”, to “Women in Modern War, Position of”. But as Huxley explained, such compression was “impossible” for some subjects. Russell evidently declined the offer (no reply is extant), for his published contribution amounted to 300 words only. It nevertheless lucidly distils a complex and contested issue. In the spirit of the publishing enterprise Russell had joined, “Causes of War” is also somewhat didactic. Yet there is little hint of either the psychological predispositions towards war he also regarded as crucial, or the absolute pacifist doctrines he had recently embraced and elaborated in Which Way to Peace? (1936). The latter ground, however, was well covered elsewhere, in entries on “Force” and “Non-Violence”, most explicitly, but also in those disparaging armed revolution, for example, or the use of sanctions to enforce international law.The two cross references at the end of Russell’s entry are probably not authorial. The text presented below is the only known version, from the cheap softcover edition of the Encyclopaedia (priced 6d ) published by Chatto & Windus under the auspices of the Peace Pledge Union—the British pacifist group of which both Huxley and Russell were sponsors, along with, in all likelihood, other of the work’s anonymous contributors. [End Page 83]CAUSES OF WARThe main causes of war are of three kinds (1) the pursuit of wealth, (2) the pursuit of glory, (3) the advocacy of a creed. Usually all three are combined in varying proportions, as, for example in the Book of Joshua. The economic motive has various forms:a. Occupation of fruitful territory—e.g. Whites and Indians in United States.b. Plunder—e.g. Romans in Asia Minor; Cortez and Pisarro.c. Trade—e.g. English and Dutch in seventeenth century.d. Markets and fields for investment—most modern imperialist wars.e. Raw materials—e.g. Japan in China, France and Germany as regards Lorraine.The notion of glory is usually dynastic or governmental—for example, the ancient Assyrians and Persians, and eighteenth-century wars so far as the Continent of Europe is concerned. But it can be made popular by propaganda, and always has been made so since the French Revolution.Creed wars may be religious or political; usually they are both. They almost always also have economic motives. The early Mohammedans, for example, had economic motives (a) and (b); the Protestants wished to secure church lands and revenues; and so on. The English Civil War combined religious and political motives in equal measure. The Albigensian crusade was, on the part of the instigators, more economic than political. The French revolutionary wars, the American Civil War, and the various civil wars since 1815, involved important politico-economic issues, and were all, in a greater or less degree, creed wars.The main causes predisposing to modern war are: first, the competition between States for markets and raw materials; secondly, the competition between classes as regards the distribution of the national wealth. These two causes are intertwined, because different governments stand for different economic systems. (See Economic Reform and Pacifism; Education and Peace.) [End Page 84]Bertrand RussellIntroduced by andrew g. bone Russell Research Centre / McMaster U. [email protected] © 2023 Bertrand Russell Research Centre, McMaster University... (shrink)

The ARXMLIV corpus is a remarkable collection of text containing scientific mathematical discourse. With more than half a million documents, it is an ambitious target for large scale linguistic and semantic analysis, requiring a generalized and distributed approach. In this paper we implement an architecture which solves and automates the issues of knowledge representation and knowledge management, providing an abstraction layer for distributed development of semantic analysis tools. Furthermore, we enable document interaction and visualization and present current implementations of semantic (...) tools and follow-up applications using this architecture. We identify five different stages, or purposes, which such architecture needs to address, encapsulating each in an independent module. These stages are determined by the different properties of the document formats used, as well as the state of processing and linguistic enrichment introduced so far. We discuss the need of migration between XML representations and the challenges it would pose on our system, revealing the benefits and trade-off of each format we employ. In the heart of the architecture lies the Semantic Blackboard module. The Semantic Blackboard comprises a system based on a centralized RDF database which can facilitate distributed corpus analysis of arbitrary applications, or analysis modules. This is achieved by providing a document abstraction layer and a mechanism for storing, reusing and communicating results via RDF stand-off annotations deposited in the central database. Achieving a properly encapsulated and automated pipeline from the input corpus document to a semantically enriched output in a state-of-the-art representation is the task of the Preprocessing, Semantic Result and Output Generation modules. Each of them addresses the task of format migration and enhances the document for further semantic enrichment or aggregation. The fifth module, targeting Visualization and Feedback, enables user interaction and display of different stages of processing.. (shrink)

Background: Electroconvulsive therapy is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging. This study aims to compare rs-fMRI of depressive disorder patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states.Method: Resting-state functional magnetic resonance imaging data were (...) collected from 119 patients with depression or depressive disorder, and 61 healthy participants, with an age mean of 52.25 years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode and cognitive control network were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants.Results: The main findings include depressive disorder patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network and default mode network was relatively higher than other states, Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes. This means that those DEP patients who spent less time in this state showed more HDRS change, and The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2.Conclusion: Our finding suggests that dynamic functional network connectivity features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients. (shrink)

Fifty years ago, 23 Nazi physicians were defendants before a military tribunal in Nuremberg, charged with crimes against humanity. During that trial, the world learned of their personal roles in human experimentation with political and military prisoners, mass eugenic sterilizations, state-ordered euthanasia of the and the program of genocide we now know as the Holocaust. These physicians, and their colleagues who did not stand trial, were universally condemned in the free world as ethical pariahs. The term became the paradigm for (...) total defection from the most rudimentary elements of medical morality. The caduceus literally became the instrument of the swastika. (shrink)

For those who are eagerly awaiting the return of Christ in glory, the admonition articulated in Matthew 24:42 has always been of paramount importance. Not only are we counseled to remain ever vigilant, but the intellectual boundaries within which we may abide in our expectation are also carefully delineated, for it is here that Christ most firmly establishes his mandate that we profess a radical agnosticism regarding the time-tables of sacred history. Nonetheless, since the days of the Church Fathers there (...) have been some who, for a variety of reasons, have sought to arrive at a more certain — or at least more refined — understanding of the timing of the Parousia, most often through a combination of exegesis and numerology. To a certain degree, Christian of Stavelot's comments on Matthew 24:42 must be considered among these attempts. (shrink)

The aim of this article is to explore some of the challenges of measuring Christian spiritual development across distinct traditions of Christian spirituality. This presses into questions of what might be universal and what might be particular when it comes to Christian spirituality in how it is understood and practiced. We address the feasibility of a general, ecumenical measure by hearing from representative voices of five traditions of Christian spirituality: African American spirituality, Anglican spirituality, Benedictine spirituality, Pentecostal spirituality, and Reformed (...) spirituality. After noting some of the distinctives of these traditions, we conclude with four strategies for navigating the unity and diversity of Christian spirituality in conceptualizing and measuring Christian formation. (shrink)

We explore ways in which purely qualitative belief change in the AGM tradition throws light on options in the treatment of conditional probability. First, by helping see why it can be useful to go beyond the ratio rule defining conditional from one-place probability. Second, by clarifying what is at stake in different ways of doing that. Third, by suggesting novel forms of conditional probability corresponding to familiar variants of qualitative belief change, and conversely. Likewise, we explain how recent work on (...) the qualitative part of probabilistic inference leads to a very broad class of 'proto-probability' functions. (shrink)

The world is about to be swamped by an unprecedented wave of AI-generated content. We need reliable ways of identifying such content, to supplement the many existing social institutions that enable trust between people and organisations and ensure social resilience. In this paper, we begin by highlighting an important new development: providers of AI content generators have new obligations to support the creation of reliable detectors for the content they generate. These new obligations arise mainly from the EU’s newly finalised (...) AI Act, but they are enhanced by the US President’s recent Executive Order on AI, and by several considerations of self-interest. These new steps towards reliable detection mechanisms are by no means a panacea—but we argue they will usher in a new adversarial landscape, in which reliable methods for identifying AI-generated content are commonly available. In this landscape, many new questions arise for policymakers. Firstly, if reliable AI-content detection mechanisms are available, who should be required to use them? And how should they be used? We argue that new duties arise for media and Web search companies arise for media companies, and for Web search companies, in the deployment of AI-content detectors. Secondly, what broader regulation of the tech ecosystem will maximise the likelihood of reliable AI-content detectors? We argue for a range of new duties, relating to provenance-authentication protocols, open-source AI generators, and support for research and enforcement. Along the way, we consider how the production of AI-generated content relates to ‘free expression’, and discuss the important case of content that is generated jointly by humans and AIs. (shrink)

We seek a better understanding of why an inferential semantics devised by Tor Sandqvist yields full classical logic, by providing and analysing a direct proof via a suitable maximality construction.

In this paper I pursue two closely related objectives. First, I articulate and describe the nature and character of Hume's theory of punishment. Second, in light of this account, I offer an assessment of the contem- porary interest and value of Hume's theory. Throughout my discus- sion I emphasize the relevance and importance of Hume's views on moral responsibility to his account of punishment.1 More specifically, I argue that Hume seeks to develop an account of punishment on the foundation of (...) a naturalistic theory of responsibility - that is, a theory which draws our attention to the role of moral sentiment in this sphere.2 Although this naturalistic aspect of Hume's theory of punishment has been largely overlooked by commentators, I maintain that it is, nevertheless, precisely this aspect of Hume's theory that is especially interesting from a contemporary pers. (shrink)

David Kellogg Lewis (1941-2001) was one of the most influential philosophers of the twentieth century. He made significant contributions to almost every area of analytic philosophy including metaphysics, philosophy of language, philosophy of mind, and philosophy of science, and set the agenda for various debates in these areas which carry on to this day. In several respects he remains a contemporary figure, yet enough time has now passed for historians of philosophy to begin to study his place in twentieth (...) century thought. His philosophy was constructed and refined not just through his published writing, but also crucially through his life-long correspondence with fellow philosophers, including leading figures such as D.M. Armstrong, Saul Kripke, W.V. Quine, J.J.C. Smart, and Peter van Inwagen. His letters formed the undercurrent of his published work and became the medium through which he proposed many of his well-known theories and discussed a range of philosophical topics in depth. A selection of his vast correspondence over a 40-year period is presented here across two volumes. The letters offer an organic story of the origins, development, breadth, and depth of his philosophy in its historical context, as well as a glimpse into the influence of his many interlocutors."-- OCLC OLUC. (shrink)

Jaswal & Akhtar provide several quotes ostensibly from people with autism but obtained via the discredited techniques of Facilitated Communication and the Rapid Prompting Method, and they do not acknowledge the use of these techniques. As a result, their argument is substantially less convincing than they assert, and the article lacks transparency.

Throughout this paper my objective will be to establish and clarify Hume's original intentions in his discussion of causation in Book I of the Treatise. I will show that Hume's views on ontology, presented in Part IV of that book, shed light on his views on causation as presented in Part III. Further, I will argue that Hume's views on ontology account for the original motivation behind his two definitions of 2 cause. This relationship between Hume's ontology and his account (...) of causation explains something which has baffled Hume scholars for some time,- namely, why does Hume's discussion of causation in I, iii, 14 have such a paradoxical air about it? I will show that Hume's views on causation have a paradoxical air about them because they rest on an ontology of "double existence" - an ontology which Hume describes as the monstrous offspring of two principles, which are contrary to each other, which are both at once embrac'd by the mind, and which are unable mutually to destroy each other (T 215) My interpretation will centre on the following two claims: (i) When Hume wrote Section 14, Of the idea of necessary connexion, he was primarily concerned to attack the view that the origin of our idea of necessity was to be discovered in the operations of matter or bodies. Of the suggested sources from which our idea of necessity could be thought to originate this is the source which, initially, interested Hume the most. It is, therefore, of great importance that we interpret Hume's remarks in light of this fact. (ii) Hume offers the first definition of cause as an account of causation as it exists in the material world independent of our thought and reasoning.He offers the second definition as an account of causation as we find it in our perceptions. It will also be argued, in this context, that necessity constitutes "an essential part" of both of Hume's two definitions of cause. (shrink)

Daniel Dennett has offered a set of necessary and sufficient conditions for something's being the proper object of our moral commitment, that is, for something's being a person. Strict application of these largely pragmatic conditions, however, would result in a moral community with quite a surprising membership roster, because of both who is on it and who isn't. The problem is that "your" being a person should amount to more than a function of "my" goals and cleverness.

Varieties of Ethical Reflection brings together new cultural and religious perspectives—drawn from non-Western, primarily Asian, philosophical sources—to globalize the contemporary discussion of theoretical and applied ethics.

The first book on my shelf at the newly created Program on Human Values and Health Sciences at the University of Tennessee Center for the Health Sciences in Memphis was by Van Rensselaer Potter on Global Bioethics. He was a cancer specialist at the University of Wisconsin and had the vision that bioethics should be a global concern—global in terms of scope, disciplines involved, and relationship to the environment and cultural context. This view has shaped my own career as well (...) as influencing many others. (shrink)

Acculturation is the process through which an individual's cultural behaviors and values change via contact with a majority or host culture. Although some individuals accomplish acculturation smoothly, most experience psychological stress during the acculturation process. When psychologists encounter individuals struggling to acculturate, they are mandated by ethical guidelines and principles to help through several steps: (a) recognize their own biases, beliefs, and attitudes that may influence their work with the acculturating individual; (b) develop competence to work with individuals whose cultural (...) beliefs and practices differ from their own; (c) counsel the acculturating individual using scientifically supported techniques; and (d) intervene without discrimination or disrespect. Two case studies are presented to illustrate how psychologists can ethically and effectively encourage mentally healthy acculturation. Keywords: acculturation, ethics, cultural differences. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:HUME, THE CAUSAL PRINCIPLE, AN'D KEMP SMITH When we say of a proposition that it is possible, we sometimes mean no more than that it is logically possible, that is, consistent with itself. A proposition can be possible in stronger senses than this, but not in any weaker one. For a sense of "p is possible" that did not entail "p is self-consistent, "would have to be a sense (...) of "p is possible" which was consistent with "p is self-inconsistent" And it is obvious that there can be no such sense as that. One of the stronger senses in which a proposition can be possible is this: consistent (with itself and in addition) with every observation-statement. (I mean by an observationstatement, a proposition which, if it were true, could in principle be discovered by experience to be true.) If a proposition? is contingent, (that is, neither necessarily true??t necessarily false), then its negation (its contradictory) not-p is contingent too; and since contingent, not necessarily false; and since not necessarily false, consistent with itself. So, given any contingent propositions, its falsity is among those propositions which are possible in the first and weak sense mentioned above. If a proposition? is not only contingent but unverifiable,(that is, not deducible from any observation- statement), then not-p is consistent both with itself and with every observation -statement. So, given any unverifiable contingent proposition, its falsity is among those propositions which are possible in the second and stronger sense mentioned above. Some stock examples. "Whatever is a raven is black" is contingent, and its falsity therefore possible in the first sense; so too is its contradictory "There are such things as non-black ravens" contingent, and its falsity possible in the first sense. But the latter proposition is not unverifiable, since there are observation-statements from which it is deducible. ("There are such things as green ravens", for example; or "A green raven was in captivity at Taronga Park Zoo in January 31st 1975".) The former proposition, on the other hand, is not only contingent but unverifiable; since there are no observation -statements from which it is deducible. Hence, "whatever is a raven is black" is a proposition the falsity of which is possible both in the first and in the second sense noticed above. A third and still stronger sense in which a proposition can be possible is the following:? is possible if and only if (p is consistent with itself,every observation-statement is consistent with p, and in addition)? is neither more nor less probable in relation to the conjunction of e and n, where e is any observation-statement and? any necessary truth, than it is in relation to? alone. The last condition may be expressed, symbolically, as "P(p/n.e) » P(p/n) for all necessarily true? and all observation-statements e"; or in Carnap' s phrase as, "every observation- statement is initially irrelevant to p." Some examples will quickly make the idea of initial irrelevance, and its opposite, more familiar; and hence will make the third sense of "p is possible" more familiar. Let? be any necessary truth and e any observation-statement. Now let? be, for- example,some necessarily false proposition; then, since P(p/n) « o = P(p/n.e), e is initially irrelevant to p. Or let? be necessarily true; then, since P(p/n) ¦ 1 = P(p/n.e), e is again initially irrelevant to p. Again, let? be "Whatever is a raven is black": then some observation- statements e are initially relevant to p. For if e is "This raven is black," for example, P(p/n.e)>P(p/n) ; or at any rate, that is what we think if we are not inductive sceptic?. Again, if? is "The Holy Ghost proceeds from the Father and the Son", it is at least very plausible to say that every observational e is initially irrelevant to p; since there appears to be no observational e such that P(p/n.e)>P(p/n), or P(p/n.e). (shrink)

Adaptive phenotypic plasticity allows organisms to cope with environmental variability, and yet, despite its adaptive significance, phenotypic plasticity is neither ubiquitous nor infinite. In this review, we merge developmental and population genetic perspectives to explore costs and limits on the evolution of plasticity. Specifically, we focus on the role of modularity in developmental genetic networks as a mechanism underlying phenotypic plasticity, and apply to it lessons learned from population genetic theory on the interplay between relaxed selection and mutation accumulation. We (...) argue that the environmental specificity of gene expression and the associated reduction in pleiotropic constraints drive a fundamental tradeoff between the range of plasticity that can be accommodated and mutation accumulation in alternative developmental networks. This tradeoff has broad implications for understanding the origin and maintenance of plasticity and may contribute to a better understanding of the role of plasticity in the origin, diversification, and loss of phenotypic diversity. (shrink)